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Immunoglobulin E and Transcription Factor in Adenoid of Children with Allergy / 대한이비인후과학회지
Article de Ko | WPRIM | ID: wpr-644875
Bibliothèque responsable: WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES: Immunoglobulin E (IgE) production in adenoid has been debated and the role of adenoid in development of allergy remains largely unknown. To examine the production of local IgE in adenoid involved with IgE-mediated sensitization, we evaluated IgE production and the expression of the transcription factor B cell leukemia/lymphoma-6 (BCL-6) and B lymphocyte inducer of maturation program 1 (Blimp-1) in adenoids. SUBJECTS AND METHOD: Ten children with allergic rhinitis (AR) and ten children without any history of AR were enrolled. Immunohistochemical studies of adenoid for IgE, BCL-6 and Blimp-1 were performed. RESULTS: IgE was stained mainly in the germinal center and submucosal area and the stainingscores of antibody to IgE did not differ signigicantly between children with AR and control. BCL- 6 was mainly stained in mucosa and germinal center and Blimp-1 in mucosa. The scores of antibody to BCL-6 and Blimp-1 in children with AR and control did not show significant differences. CONCLUSION: We found that allergic rhinitis was not involved in the production of IgE nor the expression of the transcription factor BCL-6 and Blimp-1 in adenoid
Sujet(s)
Mots clés
Texte intégral: 1 Indice: WPRIM Sujet Principal: Facteurs de transcription / Immunoglobuline E / Immunoglobulines / Lymphocytes / Tonsilles pharyngiennes / Rhinite / Rhinite spasmodique apériodique / Centre germinatif / Hypersensibilité / Muqueuse Limites du sujet: Child / Humans langue: Ko Texte intégral: Korean Journal of Otolaryngology - Head and Neck Surgery Année: 2009 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Facteurs de transcription / Immunoglobuline E / Immunoglobulines / Lymphocytes / Tonsilles pharyngiennes / Rhinite / Rhinite spasmodique apériodique / Centre germinatif / Hypersensibilité / Muqueuse Limites du sujet: Child / Humans langue: Ko Texte intégral: Korean Journal of Otolaryngology - Head and Neck Surgery Année: 2009 Type: Article