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Effect of Jak2 Inhibitor AG490 on Osteoclast Differentiation / 대한해부학회지
Korean Journal of Anatomy ; : 265-270, 2008.
Article de Ko | WPRIM | ID: wpr-645204
Bibliothèque responsable: WPRO
ABSTRACT
Osteoclasts are cells of hemopoietic origin that play an critical role in bone resorption and responsible for bone diseases, including osteoporosis, periodontal disease, and rheumatoid arthritis. In this study, we examined the effect of AG490, a Jak2-specific inhibitor on osteoclast differentiation. AG490 significantly inhibited receptor activator of NF-kappaB ligand (RANKL)-mediated osteoclast differentiation in a dose-dependent manner. RANKL stimulated the phosphorylation of p38, ERK, and JNK and promoted I-kappaB degradation. However, AG490 suppressed the phosphorylation of p38 induced by RANKL treatment. AG490 suppressed the mRNA expression of TRAP, c-Fos, NFATc1, and OSCAR in bone marrow-derived macrophages (BMMs) treated with RANKL. Also, AG490 significantly inhibited the protein expression of c-Fos and NFATc1 in response to RANKL. These results suggest that AG490 inhibited osteoclast differentiation by suppressing the expression of c-Fos and NFATc1.
Sujet(s)
Mots clés
Texte intégral: 1 Indice: WPRIM Sujet Principal: Ostéoclastes / Ostéoporose / Maladies parodontales / Phosphorylation / Polyarthrite rhumatoïde / Maladies osseuses / Résorption osseuse / ARN messager / Tyrphostines / Récepteur activateur du facteur nucléaire Kappa B langue: Ko Texte intégral: Korean Journal of Anatomy Année: 2008 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Ostéoclastes / Ostéoporose / Maladies parodontales / Phosphorylation / Polyarthrite rhumatoïde / Maladies osseuses / Résorption osseuse / ARN messager / Tyrphostines / Récepteur activateur du facteur nucléaire Kappa B langue: Ko Texte intégral: Korean Journal of Anatomy Année: 2008 Type: Article