Rare Presentation of Richter's Transformation to Diffuse Large B Cell Lymphoma: a Case Report / 대한내과학회지
Korean Journal of Medicine
; : 163-168, 2016.
Article
Dans Ko
| WPRIM
| ID: wpr-65764
Responsable en Bibliothèque :
WPRO
ABSTRACT
Richter's syndrome refers to the development of aggressive lymphoma in a patient with chronic lymphocytic leukemia (CLL). It occurs in about 2% to 10% of patients with CLL. The most frequent manifestation of Richter's syndrome is diffuse large B cell lymphoma (DLBCL). Extranodal involvement is rare but can occur. The prognosis of Richter's syndrome is very poor. We herein report a case of a rare presentation of Richter's syndrome. A 42-year-old man diagnosed with CLL 2 years previously developed nodules on the bilateral thighs and buttocks. A positron emission tomography (PET)-CT scan revealed high fluorodeoxyglucose uptake in multiple lymph nodes, skeletal muscles, and the myocardium. An ultrasonography-guided biopsy confirmed Richter's syndrome from CLL to DLBCL. The patient was treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy. After six cycles of chemotherapy, we performed a PET-CT scan that revealed a complete response. However, 3 months later, the syndrome recurred. The patient was undergoing salvage chemotherapy at the time of this writing.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pronostic
/
Cuisse
/
Vincristine
/
Écriture
/
Biopsie
/
Fesses
/
Prednisone
/
Leucémie chronique lymphocytaire à cellules B
/
Doxorubicine
/
Lymphome B
Type d'étude:
Prognostic_studies
Limites du sujet:
Adult
/
Humans
langue:
Ko
Texte intégral:
Korean Journal of Medicine
Année:
2016
Type:
Article