Biomedical effects of TRIP-Br2 / 上海交通大学学报(医学版)
Journal of Shanghai Jiaotong University(Medical Science)
; (12): 1438-1440, 2017.
Article
Dans Zh
| WPRIM
| ID: wpr-660644
Responsable en Bibliothèque :
WPRO
ABSTRACT
TRIP-Br2 (transcriptional regulator interacting with the PHD zinc finger and/or the bromodomain 2) is a kind of cell cycle regulator, which can specifically bind to transcription factor DP-1 (DRTF-1-polypeptide-1) and participate in E2F-1 (E2 factor-1)/DP-1-mediated transcriptional proliferative activities and maintain genome stability. As for energy metabolism, overexpression of TRIP-Br2 activates E2F-1/DP-1-mediated cell cycle regulation,leading to decreased genomic stability and promoting oncogenesis. High levels of TRIP-Br2 can induce brown adipocytes to release inflammatory factors and acute phase response proteins, producing inflammatory responses and acute phase responses. This paper summarizes the molecular structure of TRIPBr2 and its biological role in proliferation, metabolism, and inflammation.
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WPRIM
langue:
Zh
Texte intégral:
Journal of Shanghai Jiaotong University(Medical Science)
Année:
2017
Type:
Article