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Research progress of hepatocyte necroptosis in liver injuries / 中国药理学通报
Chinese Pharmacological Bulletin ; (12): 1651-1655, 2017.
Article de Zh | WPRIM | ID: wpr-667983
Bibliothèque responsable: WPRO
ABSTRACT
Various pathological factors can result in the death of hepatocytes during liver injury. Persistent hepatocyte death initi-ates and aggravates chronic inflammation and fibrosis,ultimately leading to liver cirrhosis and hepatocellular carcinoma. Thus, limiting hepatocyte death is an effective strategy for improving liver injury. Necroptosis is a newly characterized form of cell death,which is highly regulated by signaling pathways and has typical morphological features of necrosis. Increasing evidence indicates that necroptosis plays a key role in drug-induced or im-munological acute liver injuries,and in chronic liver injuries in-cluding alcoholic fatty liver,nonalcoholic fatty liver and liver fi-brosis. This article reviews the recent advances on the hepato-cyte necroptosis in liver injury,providing novel insights into the pathogenesis of liver disease and related therapeutic reagents.
Mots clés
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Chinese Pharmacological Bulletin Année: 2017 Type: Article
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Chinese Pharmacological Bulletin Année: 2017 Type: Article