Iodine-rich diet and thyroid cancer: a Meta-analysis / 中华地方病学杂志

ABSTRACT

Objective To explore the relationship between iodine-rich diet and thyroid cancer.Methods PubMed,Excerpt Medica Database (EMbase),China National Knowledge Infrastructure (CNKI),WanFang,WeiPu,and China Biology Medicine disc (CBM) were searched through computer,for relevant articles published before June 2016,to find case-control studies concerning the relationship between iodine-rich diet and thyroid cancer.According to the inclusion and exclusion criteria for data extraction and quality evaluation,Meta-analysis was performed using Stata 12.0.Results Totally 19 case-control studies were included in this study.Cases and controls were 47 316 people (case 6 662,control 40 654).The quality of the literature was reliable (the score was 6 points and more).Meta analysis results showed a total of 13 articles studied fish,more frequent intake (3 times per week and more) of fish can reduce the risk of thyroid cancer [odds ratio (OR) =0.87,95％ confidence interval (CI)0.77-0.98,P ＜ 0.05];except saltwater fish,a total of 16 articles studied seafood,more frequent intake of seafood (3 times per week and more) increases the risk of thyroid cancer (OR =1.48,95％CI1.11-1.99,P＜ 0.05).Study factors subgroup analysis showed that seafood (OR =2.23,95％CI1.45-3.45,P ＜ 0.05),marine animal food (OR =9.48,95％CI5.03-17.88,P ＜ 0.05) and seaweed (OR =1.93,95％CI1.39-2.69,P ＜ 0.05) can increase the risk of thyroid cancer,shellfish (OR =1.21,95％CI0.94-1.56,P ＞ 0.05),saltwater fish (OR =0.94,95％CI0.50-1.77,P ＞ 0.05)and freshwater fish (OR =0.90,95％CI0.66-1.21,P ＞ 0.05) had no effect on the prevalence of thyroid cancer.Conclusion Seafood,marine animal foods and seaweed will increase the risk of thyroid cancer.