Dendritic cells activated by tumor antigen to treat bladder tumor in mouse / 中国癌症杂志

ABSTRACT

Purpose:To study the feasibility of GM CSF and the tumor antigen activated dendritic cells in treating bladder tumor in rats.Methods:The DCs isolated from the spleen of T739 mice which were stimulated in vitro by syngenic granulocyte macrophage colony stimulating factor (GM CSF) and irradiated inactivated BTT739 Bladder tumor cells(Group D),were transfused intravenously once a week when BTT739 tumor cells were inoculated in mouse. Group A was established as control,group B and C were injected with GM CSF activated DCs and inactivated tumor vaccine.Results:In group D, the CTL activity against the BTT739 tumor and cytokine IL 4 and IFN ? was significantly higher than those in other groups ( P