Human parvovirus B19 infection in patients with systemic lupus erythematosus / 中华风湿病学杂志
Chinese Journal of Rheumatology
; (12)2003.
Article
Dans Zh
| WPRIM
| ID: wpr-682676
Responsable en Bibliothèque :
WPRO
ABSTRACT
Objective To investigate the relationship between parvovirus B19 infection and systemic lupus erythematosus(SLE).Methods Sera from 51 patients with SLE and 20 normal controls were exam- ined for IgG and IgM antibodies against parvovirus BI9 by ELISA(produced by IBL Hamburg Company, Germany).Results Anti-Bl9 antibodies were found more frequently in sera from SLE patients than in normal controls,IgM and [gG antibodies were detected in 11(17.65%)and 9(21.57%)of 51 SLE pa- tients respectively.It was observed that the SLEDAI scores were higher in patients with B19 IgM positive group than those of the negative group(P<0.05).The sera levels of ALT/AST were elevated more frequently in patients with BI9 IgM positive group than in negative group(P<0.05).However,there was no association between the presence of anti-IgM and clinical manifestations in patients with SLE(P>0.05).Five SLE pa- tients with positive B19 IgM were followed up for 2 years.SLEDA1 scores of these patients were markedly decreased(P<0.05),but the levels of auto-antibodis(ANA,dsDNA)didn't change(P>0.05).And the levels of ALT/AST decreased as usual.Conclusions It is suggested that parvovirus B19 infection may ex- acerbate the onset of SLE,but we eould not find a correlation between parvovirus B19 infection and prog- nosis of the disease.
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WPRIM
langue:
Zh
Texte intégral:
Chinese Journal of Rheumatology
Année:
2003
Type:
Article