Result Analysis on Bacterial Culture and Drug Susceptibility of Fetal Membranes in Women with Premature Rupture of Membranes / 实用妇产科杂志

ABSTRACT

Objective..To analyze the bacterial distribution and drug resistance of fetal membrane sample from women suffered premature rupture of membranes(PROM),so as to provide evidence for rational use of antibiotics.Methods:A total of 1041 fetal membrane samples in women with premature rupture of membranes were cultured and drug susceptibility tests were done.Among those samples,258 of them came from women who had used antibiotics during prenatal period,while the others came from women who unused.Results:Among the 1041 fetal membrane samples,369 (35.4％) were infected.The infection of Gram-negative bacteria accounted for 66.7％,whereas gram positive bacteria accounted for 33.1％.The expectant time prolonged,and the positive rate of infection from women with PROM did not increase(P ＞0.05),whereas the positive rate of infection among PPROM increased(P＜0.05).There were 35 strains of bacteria identified in non-antibiotics group during prenatal period,while 17 strains of bacteria were identified in the antibiotics group.The main strain was Escherichia coli which accounted for 59.7％.Escherichia coli were resistant to piperacillin,ampicillin and tetracycline.For the mentioned drugs,the resistance rates were all above 45.0％.The resistance rate of Escherichia coli in antibiotics group was higher than that in the non-antibiotics group(P ＜0.05).The resistance rate of Gram positive bacteria to Nitrofurantoin,Teicoplanin,Vancomycin and Linezolid was 0.Conclusions:Escherichia coli is the main pathogenic bacteria isolated from fetal membrane samples of women with premature rupture of membranes.It is important to use antibiotics rationally according to the feature of pathogenic bacteria.