Growth Inhibition of Human Uterine Leiomyoma Cells by Selective Estrogen Receptor Modulator / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
; : 1071-1079, 2004.
Article
de Ko
| WPRIM
| ID: wpr-70131
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE: Our purpose was to evaluate potential efficacy of selective estrogen receptor modulators (raloxifene and tamoxifen) to human uterine leiomyoma cells. METHODS: The samples were collected from ten hysterectomized specimen. we evaluated the estrogen-responsive growth of human uterine leiomyoma and normal myometrial cells. The potential efficacy of Selective Estrogen Receptor Modulators (SERMs: raloxifene and tamoxifen) to human uterine leiomyoma cells were conducted by MTS, cell count assay and Western-blot. RESULTS: Human uterine leiomyoma and normal myometrial cells that expressed estrogen receptor (ER) showed increases the cell number in the presence of estrogen compared with ER negative uterine leiomyoma cells. Raloxifene and tamoxifen inhibited estrogen-stimulated proliferation of ER-containing human uterine leiomyoma and normal myometrial cells. Raloxifene was more effective in inhibiting estrogen-induced increases of cell number compared with tamoxifen. CONCLUSION: The effect of SERMs on leiomyoma was inhibited the cell proliferation without apoptosis or cell cycle arrest. These data suggest that SERM should be examined as candidate of nonsurgical therapeutic agents for uterine leiomyoma.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Tamoxifène
/
Numération cellulaire
/
Apoptose
/
Chlorhydrate de raloxifène
/
Modulateurs sélectifs des récepteurs des oestrogènes
/
Prolifération cellulaire
/
Oestrogènes
/
Points de contrôle du cycle cellulaire
/
Léiomyome
Limites du sujet:
Humans
langue:
Ko
Texte intégral:
Korean Journal of Obstetrics and Gynecology
Année:
2004
Type:
Article