Comparison of the effects of different blood purification methods on inflammatory cytokines clearance in patients with maintenance hemodialysis / 中国基层医药

ABSTRACT

Objective To compare the effects of different ways of blood purification on inflammatory cytokines clearance in patients with maintenance hemodialysis.Methods The clinical data of 50 patients with maintenance hemodialysis were retrospectively analyzed.The low flux dialysis,high flux dialysis were used respectively,and the changes of hypersensitive C-reactive protein (hs-CRP),tumor necrosis factor alpha (TNF-α),interleukin 1 (IL-1),interleukin 6 (IL-6) after dialysis were compared between the two methods.Results After low flux dialysis,the hs-CRP,TNF-α,IL-1,IL-6 levels were (6.58 ± 3.69) mg/L,(1.54 ± 0.42) g/L,(105.46 ±8.20) ng/L,(27.58 ± 6.83) ng/L,respectively,which after high flux dialysis were (2.93 ± 1.85) mg/L,(1.13 ±0.27) g/L,(97.21 ± 7.l4.) ng/L,(20.35 ± 5.76) ng/L,respectively,the differences were statistically significant (t =6.253,5.806,5.365,5.806,all P ＜ 0.05).Conclusion Compared with the low flux dialysis,high flux dialysis is more effective in inflammatory cytokines clearance in patients with maintenance hemodialysis.