Design, synthesis and biological evaluation of pyridine-based IRAK4 inhibitors / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 670-674, 2017.
Article
de Zh
| WPRIM
| ID: wpr-704301
Bibliothèque responsable:
WPRO
ABSTRACT
Based on the known IRAK4 inhibitors MK-32 and AU-5,we designed and synthesized 12 pyridine-based target compounds by adopting open-ring and hybrid strategies,and combining molecular docking technology.The bioassays determined by radioisotope labeling demonstrated that the target compounds displayed good inhibitory activity against IRAK4.Among them,the IC50 value of 5 compounds was less than 1 μmol/L,suggesting that these compounds may be candidates for further investigation.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Journal of China Pharmaceutical University
Année:
2017
Type:
Article