Design,synthesis and biological evaluation of phenylsulfonamide-based IDO1 inhibitors / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 34-38, 2018.
Article
Dans Zh
| WPRIM
| ID: wpr-704319
Responsable en Bibliothèque :
WPRO
ABSTRACT
Based on the reported IDO1 inhibitor U-3i,11 phenylsulfonamide derivatives were designed and syn-thesized by adopting bioisosterism and molecular docking technology.The inhibitory activities of the target compounds against IDO1 were determined by the HeLa cell-based kynurenine assay.The results demonstrated that most compounds showed different degrees of inhibitory effects on IDO1.Among them,compounds 3b and 3e displayed the most potent activity and could reverse IDO1-mediated immune suppression,which might be worth of further investigation.
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WPRIM
langue:
Zh
Texte intégral:
Journal of China Pharmaceutical University
Année:
2018
Type:
Article