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Expression and Correlation of PHF20 and Apoptosis-associated Protein Bax in Non-small Cell Lung Cancer / 中国医科大学学报
Journal of China Medical University ; (12): 887-890,902, 2017.
Article de Zh | WPRIM | ID: wpr-704910
Bibliothèque responsable: WPRO
ABSTRACT
Objective To investigate the differences in the expression of PHF20 and Bax and their correlations in non-small cell lung cancer before chemotherapy.Methods An immunohistochemical method was used to detect the expression of PHF20 and Bax in non-small cell lung cancer,and to analyze the clinical significance of PHF20 and the possible correlation between PHF20 and Bax proteins.Results PHF20 protein is expressed in the cytoplasm of non-small cell lung cancer cells.Moreover,it is highly expressed in squamous cell carcinoma,less expressed in adenocarcinoma,and closely related with cell differentiation,TNM staging,and lymph node metastasis.The expression of PHF20 and Bax was positively correlated with squamous cell lung carcinoma.Conclusion The expression of PHF20 in non-small cell lung cancer is closely associated with tumor progression and the expression of Bax.PHF20 may be a new target for the treatment of non-small cell lung cancer.
Mots clés
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Journal of China Medical University Année: 2017 Type: Article
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Journal of China Medical University Année: 2017 Type: Article