Advances in small molecular drugs targeted mutant p53 / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 321-324, 2018.
Article
de Zh
| WPRIM
| ID: wpr-705040
Bibliothèque responsable:
WPRO
ABSTRACT
Tumor suppressor p53 protein can regulate the tran-scription of target genes, to control cell apoptosis, aging and other life activities,but mutant p53 is prone to losing antitumor function, thus promoting tumor development. At present, p53 protein has become one of the hot targets for the treatment of cancer. This article mainly introduces the structure and mechanism of small molecular compounds with restoring activity of mutant p53 as the target.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Pharmacological Bulletin
Année:
2018
Type:
Article