An analysis on the clinical application value of MR-DWI in the early diagnosis of PCa / 中国医学装备

ABSTRACT

Objective: To explore the value of magnetic resonance (MR) diffusion weighted imaging (DWI) in the early diagnosis of prostate cancer (PCa). Methods: 61 patients with PCa were enrolled in the observation group, and 70 patients with benign prostatic hyperplasia were divided into the control group. DWI scan (b=800 s/mm2) was performed on each patients of two groups, and all of patients of two groups were confirmed by aspiration biopsy or pathology of operation. Results: Pathological results found that there were 81 PCa lesions, which including 32 central glandular lesions and 49 surrounding lesions, and 118 benign prostatic hyperplasia nodules. The sensitivity, specificity and accuracy of DWI for diagnosing PCa were 80.25%, 75.42% and 77.39%, respectively. The detection rates of central glandular lesions and surrounding lesions detected by DWI were 78.13% and 81.63%, respectively, and the difference was not statistically significant (x2=0.150, P>0.05). The apparent diffusion coefficient (ADC) value of PCa lesions was (0.90±0.21)×10-3mm2/s, which was significantly lower than that of benign prostatic hyperplasia nodules (1.52±0.26) ×10-3mm2/s, and the difference was statistically significant (t=17.833, P<0.05). While there was no significant difference for the ADC value between central glandular lesions and surrounding lesions (t=1.143, P>0.05). The area under the curve (AUC) of receiver operating characteristic (ROC) of PCa lesions that diagnosed by using ADC was 0.977(P<0.05), and when cut-off value of ADC was 1.22×10-3mm2/s, the sensitivity and specificity of diagnosing PCa of ADC were 91.60% and 92.59%, respectively. Conclusion: DWI has a certain value in the early diagnosis of PCa, and the diagnostic value of ADC is higher.