Expression and diagnostic value of serum miR-26a/b in patients with gastric cancer / 中国肿瘤临床
Chinese Journal of Clinical Oncology
; (24): 1242-1247, 2017.
Article
Dans Zh
| WPRIM
| ID: wpr-706739
Responsable en Bibliothèque :
WPRO
ABSTRACT
Objective:
To discuss the diagnostic value of miR-26a/b and relationship of this microRNA with clinicopathological features in patients with gastric cancer.Methods:
The expression of serum miR-26a/b was detected in 121 patients with gastric cancer and 116 healthy controls using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). The relationship of miR-26a/b and clinicopathological parameters of patients were analyzed. The receiver operating curve (ROC) was constructed to in vestigate the value of miR-26a/b in the diagnosis of gastric cancer.Results:
The relative expression levels of serum miR-26a and miR-26b in patients with gastric cancer were lower than those in the control group (1.60±1.02 vs. 5.35±0.44;1.44±0.71 vs. 5.35±0.71;P<0.05). The relative expression level of miR-26a/b correlated with TNM stage, and the relative expression level of miR-26a also correlated with invasion depth and lymph node metastasis (P<0.05), but not with sex, age, tumor size, or histological type (P>0.05). The area under the ROC curve of miR-26a was 0.828 (95%CI0.776~0.881), with sensitivity of 73.3%and specificity of 81.0%, while the area under the ROC curve of miR-26b was 0.853 (95%CI0. 801~0.906), with sensitivity of 68.1%and specificity of 99.2%.Conclusion:
The expression of miR-26a/b significantly reduced in patients with gastric cancer, and its expression level correlated with the clinical stage, invasion depth, and lymph node metastasis. MiR-26a/b has potential diagnostic value for gastric cancer.
Texte intégral:
1
Indice:
WPRIM
Type d'étude:
Diagnostic_studies
/
Prognostic_studies
langue:
Zh
Texte intégral:
Chinese Journal of Clinical Oncology
Année:
2017
Type:
Article