Your browser doesn't support javascript.
loading
Improvement of Persistent Detrusor Overactivity through Treatment with a Phytotherapeutic Agent (WSY-1075) after Relief of Bladder Outlet Obstruction
Article de En | WPRIM | ID: wpr-714390
Bibliothèque responsable: WPRO
ABSTRACT
PURPOSE: Many patients with benign prostatic hyperplasia need treatment for remaining storage symptoms after surgery. Therefore, we evaluated the effect of the phytotherapeutic agent WSY-1075 on persistent detrusor overactivity (DO) after the relief of bladder outlet obstruction (BOO). MATERIALS AND METHODS: Rats were assigned to 3 groups: control (n=6), persistent DO (n=6), and persistent DO treated with the phytotherapeutic agent WSY-1075 (n=6). Persistent DO after relief of partial BOO was generated in the rat model, and 6 of the rats with this condition were orally administered WSY-1075. After 4 weeks of administration, cystometry was performed. Additionally, 8-hydroxy-2-deoxyguanosine and superoxide dismutase were measured to evaluate oxidative stress in the bladder. Pro-inflammatory cytokines, such as interleukin-8 and tumor necrosis factor-α, were analyzed, as were the M2 and M3 muscarinic receptors of the bladder. RESULTS: Significantly increased contraction pressure and a decreased contraction interval were observed in the persistent DO group after relief of BOO. Moreover, oxidative stress, pro-inflammatory cytokines, and M3 muscarinic receptors were significantly increased. After treatment with WSY-1075, significantly reduced DO was observed by cystometry in comparison with the persistent DO group. Additionally, significantly decreased levels of oxidative stress, pro-inflammatory cytokines, and M3 muscarinic receptors in the bladder were observed after treatment with WSY-1075. CONCLUSIONS: Treatment with WSY-1075 improved persistent DO after the relief of BOO mediated by antioxidative and anti-inflammatory effects. Further studies are necessary to identify the exact mechanism of the treatment effect of WSY-1075.
Sujet(s)
Mots clés
Texte intégral: 1 Indice: WPRIM Sujet Principal: Hyperplasie de la prostate / Superoxide dismutase / Vessie urinaire / Obstruction du col de la vessie / Cytokines / Interleukine-8 / Récepteur muscarinique / Stress oxydatif / Modèles animaux / Vessie hyperactive Type d'étude: Prognostic_studies Limites du sujet: Animals / Humans langue: En Texte intégral: The World Journal of Men's Health Année: 2018 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Hyperplasie de la prostate / Superoxide dismutase / Vessie urinaire / Obstruction du col de la vessie / Cytokines / Interleukine-8 / Récepteur muscarinique / Stress oxydatif / Modèles animaux / Vessie hyperactive Type d'étude: Prognostic_studies Limites du sujet: Animals / Humans langue: En Texte intégral: The World Journal of Men's Health Année: 2018 Type: Article