Primary malignant melanoma of the uterine cervix treated with pembrolizumab after radical surgery: a case report and literature review
Obstetrics & Gynecology Science
; : 524-528, 2018.
Article
de En
| WPRIM
| ID: wpr-715700
Bibliothèque responsable:
WPRO
ABSTRACT
Malignant melanoma of the genital tract is a rare disease that is usually diagnosed by chance. When a definite diagnosis is delayed, the prognosis is very poor without standardized treatment. Herein, we describe a 40-year-old patient who presented with a history of bloody vaginal discharge for 7 months. Gynecological examination showed an exophytic, hard and pigmented cervical mass involving the upper vagina. The patient was diagnosed with cervical melanoma after a punch biopsy and underwent a radical hysterectomy, upper vaginectomy, bilateral salpingo-oophorectomy and pelvic lymphadenectomy. After surgeries, the patient underwent 2-cycles of adjuvant immunotherapy with pembrolizumab, but died within 8 months. In this report, treatment with pembrolizumab after radical surgery was not effective for this patient who had a primary cervical melanoma that metastasized to bone and lung tissue. We do not know why pembrolizumab was ineffective for this patient, but there are several possible explanations; further research is needed.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pronostic
/
Vagin
/
Biopsie
/
Tumeurs du col de l'utérus
/
Col de l'utérus
/
Perte vaginale
/
Maladies rares
/
Diagnostic
/
Examen gynécologique
/
Anticorps monoclonaux humanisés
Type d'étude:
Diagnostic_studies
/
Prognostic_studies
Limites du sujet:
Adult
/
Female
/
Humans
langue:
En
Texte intégral:
Obstetrics & Gynecology Science
Année:
2018
Type:
Article