Changes of the growth plate in children: 3-dimensional magnetic resonance imaging analysis / 소아과
Korean Journal of Pediatrics
; : 226-230, 2018.
Article
Dans En
| WPRIM
| ID: wpr-715807
Responsable en Bibliothèque :
WPRO
ABSTRACT
PURPOSE:
This pilot study assessed changes in the growth plate and growth rates in children during a 6-month period.METHODS:
The study included 31 healthy children (17 boys, 14 girls) under evaluation for growth retardation. Height, weight, bone age, insulin like growth factor-1 (IGF-1), and insulin like growth factor binding protein 3 (IGF-BP3) were measured at baseline and after 6 months. In addition, the diameter, thickness, and volume of the femoral and tibial growth plates were measured using magnetic resonance imaging.RESULTS:
The mean bone age in boys and girls was 11.7 and 10.7 years, respectively. In boys, height (z score) (−0.2 vs. 0.0), weight (z score) (0.8 vs. 1.1), body mass index (BMI) (z score) (1.27 vs. 1.5), IGF-1 (ng/mL) (343.6 vs. 501.8), and IGF-BP3 (ng/mL) (5,088.5 vs. 5,620.0) were significantly higher after 6 months. In girls, height (z score) (−1.0 vs. −0.7), weight (z score) (−0.5 vs. 0.1), BMI (z score) (−0.02 vs. 0.3), IGF-1 (ng/mL) (329.3 vs. 524.6), and IGF-BP3 (ng/mL) (4,644.4 vs. 5,593.6) were also significantly higher after 6 months. In both sexes, the mean diameter and volume of the femoral and tibial growth plates were significantly increased 6 months later.CONCLUSION:
No significant correlation was found between changes in the growth plate and clinical parameters in children with growth retardation in this study, other than correlations of change in femoral diameter with weight and BMI. A larger, long-term study is needed to precisely evaluate the correlation between change in the growth plate and growth.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Facteur de croissance IGF-I
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Imagerie par résonance magnétique
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Protéines de transport
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Indice de masse corporelle
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Projets pilotes
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Lame épiphysaire
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Insuline
Limites du sujet:
Child
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Female
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Humans
langue:
En
Texte intégral:
Korean Journal of Pediatrics
Année:
2018
Type:
Article