Large Cell Neuroendocrine Carcinoma of the Colon With Carcinomatosis Peritonei
Annals of Coloproctology
; : 222-225, 2018.
Article
de En
| WPRIM
| ID: wpr-716194
Bibliothèque responsable:
WPRO
ABSTRACT
Colorectal large-cell neuroendocrine carcinomas (NECs) are extremely rare and have very poor prognosis compared to adenocarcinomas. A 74-year-old man presented with abdominal pain, diarrhea and hematochezia. The histopathologic report of colonoscopic biopsy performed at a local clinic was a poorly differentiated carcinoma. An abdominopelvic computed scan revealed irregularly enhanced wall thickening at the sigmoid colon with regional fat stranding and lymphnode enlargement. He underwent a laparoscopic high anterior resection with selective peritonectomy for peritoneal carcinomatosis, intraoperative peritoneal irrigation chemotherapy, and early postoperative intraperitoneal chemotherapy for 5 days. The tumor had a high proliferation rate (mitotic count > 50/10 HPFs and 90% of the Ki-67 index) and lymph-node metastases had occurred. On immunohistochemistry, the tumor cells expressed CD56 and synaptophysin. Large-cell NEC was confirmed. Systemic chemotherapy with cisplatin/etoposide was done. The patient is still alive after 3 years with no evidence of recurrence.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pronostic
/
Récidive
/
Côlon sigmoïde
/
Biopsie
/
Immunohistochimie
/
Lavage péritonéal
/
Carcinomes
/
Adénocarcinome
/
Douleur abdominale
/
Synaptophysine
Type d'étude:
Prognostic_studies
Limites du sujet:
Aged
/
Humans
langue:
En
Texte intégral:
Annals of Coloproctology
Année:
2018
Type:
Article