Neural Signature for Auditory Hallucinations in Schizophrenia: A High-Resolution Positron Emission Tomography Study with Fludeoxyglucose (¹⁸F)
Clinical Psychopharmacology and Neuroscience
; : 324-332, 2018.
Article
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| ID: wpr-716301
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ABSTRACT
OBJECTIVE:
Auditory hallucinations (AHs) are a core symptom of schizophrenia. We investigated the neural signature of AHs by comparing hallucinating patients with schizophrenia with non-hallucinating patients with schizophrenia.METHODS:
We recruited hallucinating patients with schizophrenia meeting the criteria for persistent, prominent, and predominant AHs (n=10) and non-hallucinating patients with schizophrenia (n=12). Various clinical assessments were performed incluing Psychotic Symptom Rating Scale for Auditory Hallucinations. Using fludeoxyglucose (¹⁸F) positron emission tomography, regional differences in neural activity between the groups were analyzed.RESULTS:
The regions of interest analysis showed significantly lower standardized uptake value ratio (SUVR) in the superior, middle, and inferior frontal gyri, and higher SUVR in the putamen in patients with AHs versus patients without AHs. These findings were confirmed in the voxel-wise analysis.CONCLUSION:
Our findings indicate that hypoactivity in the frontal and cingulate gyri, coupled with hyperactivity in the temporal gyrus and putamen, may contribute to the pathophysiology of AHs.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Putamen
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Schizophrénie
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Lobe temporal
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Tomographie par émission de positons
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Électrons
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Hallucinations
Limites du sujet:
Humans
langue:
En
Texte intégral:
Clinical Psychopharmacology and Neuroscience
Année:
2018
Type:
Article