HBsAg-Negative, Anti-HBc–Negative Patients Still Have a Risk of Hepatitis B Virus–Related Hepatitis after Autologous Stem Cell Transplantation for Multiple Myeloma or Malignant Lymphoma / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 1121-1129, 2018.
Article
de En
| WPRIM
| ID: wpr-717453
Bibliothèque responsable:
WPRO
ABSTRACT
PURPOSE: Although hepatitis B surface antigen (HBsAg)–negative, hepatitis B core antibody (anti-HBc)–negative patients are not considered to be at risk for hepatitis B virus (HBV)–related hepatitis, the actual risk remains to be elucidated. This study aimed to evaluate the risk of HBV-related hepatitis in HBsAg-negative, anti-HBc–negative patients receiving autologous stem cell transplantation (ASCT) for multiple myeloma (MM) or malignant lymphoma. MATERIALS AND METHODS: We retrospectively reviewed data from 271 HBsAg-negative patients (161 anti-HBc–negative and 110 anti-HBc–positive at the time of ASCT) who received ASCT for MM or lymphoma. The risk of HBV-related hepatitis was analyzed according to the presence of anti-HBc. HBV serology results at the time of ASCT were compared with those at the time of diagnosis of MM or lymphoma. RESULTS: Three patients (two anti-HBc–negative MMs and one anti-HBc–positive MM) developed HBV-related hepatitis after ASCT. The rate of HBV-related hepatitis did not differ among patients with or without anti-HBc status (p=0.843). HBV-related hepatitis more frequently occurred in MM patients than in lymphoma patients (p=0.041). Overall, 9.1% of patients (16.7% with MM and 5.4% with lymphoma) who were HBsAg–negative and anti-HBc–positive at the time of diagnosis had lost anti-HBc positivity during chemotherapy prior to ASCT. CONCLUSION: Our data suggest that HBsAg-negative, anti-HBc–negative patients at the time of ASCT for MM or lymphoma still might be at a risk for HBV-related hepatitis.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Cellules souches
/
Virus de l'hépatite B
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Études rétrospectives
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Transplantation de cellules souches
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Diagnostic
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Traitement médicamenteux
/
Hépatite
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Hépatite B
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Antigènes de surface du virus de l'hépatite B
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Lymphomes
Type d'étude:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
Limites du sujet:
Humans
langue:
En
Texte intégral:
Cancer Research and Treatment
Année:
2018
Type:
Article