Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 1462-1466, 2018.
Article
de En
| WPRIM
| ID: wpr-717507
Bibliothèque responsable:
WPRO
ABSTRACT
Chimeric antigen receptor T-cell strategy targeting CD19 (CART19) has prominent anti-tumor effect for relapsed/refractory B-cell lymphomas. CART19-associated complications have been gradually recognized, however, late-onset complications have not been extensively studied. Herein, for the first time we report a diffuse large B-cell lymphoma patient with terminal ileum involvement obtained rapid remission and developed spontaneous terminal ileal perforation 38 days following CART19 infusion. The late-onset perforation reminds us that, for the safety of CART treatment, more cautions are warranted for the management of delayed GI complications.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Lymphocytes B
/
Récepteurs aux antigènes
/
Lymphocytes T
/
Lymphome B
/
Iléum
Limites du sujet:
Humans
langue:
En
Texte intégral:
Cancer Research and Treatment
Année:
2018
Type:
Article