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Effect of Adjuvant Chemotherapy on Stage II Colon Cancer: Analysis of Korean National Data / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 1149-1163, 2018.
Article de En | WPRIM | ID: wpr-717752
Bibliothèque responsable: WPRO
ABSTRACT
PURPOSE: Debates exist regarding the effectiveness of adjuvant chemotherapy for stage II colon cancer. This study aimed to investigate the current status of adjuvant chemotherapy and its impact on survival for Korean stage II colon cancer patients by analyzing the National Quality Assessment data. MATERIALS AND METHODS: A total of 7,880 patientswho underwent curative resection for stage II colon adenocarcinoma between January 2011 andDecember 2014 in Koreawere selected randomly as evaluation subjects for the quality assessment. The factors that influenced overall survival were identified. The high-risk group was defined as having at least one of the following: perforation/obstruction, lymph node harvest less than 12, lymphovascular/perineural invasion, positive resection margin, poor differentiation, or pathologic T4 stage. RESULTS: The median follow-up period was 38 months (range, 1 to 63 months). Chemotherapy was a favorable prognostic factor for either the high- (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.38 to 0.59; p < 0.001) or low-risk group (HR, 0.74; 95% CI, 0.61 to 0.89; p=0.002) in multivariate analysis. This was also the case in patients over 70 years of age. The hazard ratio was significantly increased as the number of involved risk factors was increased in patients who didn’t receive chemotherapy. Adding oxaliplatin showed no difference in survival (HR, 1.36; 95% CI, 0.91 to 2.03; p=0.132). CONCLUSION: Adjuvant chemotherapy can be recommended for stage II colon cancer patients, but the addition of oxaliplatin to the regimen must be selective.
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Texte intégral: 1 Indice: WPRIM Sujet Principal: Adénocarcinome / Analyse multifactorielle / Facteurs de risque / Études de suivi / Résultat thérapeutique / Traitement médicamenteux adjuvant / Côlon / Tumeurs du côlon / Traitement médicamenteux / Noeuds lymphatiques Type d'étude: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limites du sujet: Humans langue: En Texte intégral: Cancer Research and Treatment Année: 2018 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Adénocarcinome / Analyse multifactorielle / Facteurs de risque / Études de suivi / Résultat thérapeutique / Traitement médicamenteux adjuvant / Côlon / Tumeurs du côlon / Traitement médicamenteux / Noeuds lymphatiques Type d'étude: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limites du sujet: Humans langue: En Texte intégral: Cancer Research and Treatment Année: 2018 Type: Article