Your browser doesn't support javascript.
loading
Cell Differentiation Might Predict the Recurrence in Surgically Resected Non-Small Cell Lung Carcinoma / 결핵및호흡기질환
Article de Ko | WPRIM | ID: wpr-71781
Bibliothèque responsable: WPRO
ABSTRACT
BACKGROUND: Lung cancer is the most common cause of cancer mortality in Korea. The TNM stage at presentation in patients with non-small cell lung cancer (NSCLC) has the greatest impact on prognosis. Patients who undergo a complete resection for NSCLC are likely to develop recurrent and/or metastatic disease. There are several factors influencing the development of recurrence. We explored risk factors of recurrence in patients with stages I and II NSCLC, who had undergone curative resection. METHODS: We reviewed patients who had complete surgical resection as definitive treatment for stage I or II. Patients followed up for more than 36 months. We evaluated several factors which might have relationship with recurrence, such as patient's demographic factors, TNM staging, pathologic finding, tumor markers and surgical technique. RESULTS: A total of 75 patients were enrolled for analysis, of whom 58 were men and 17 were women with mean age of 61 (range, 37 to 76) years. The average size of tumors was 3.9 cm (0.7 to 10 cm). There were 64 patients with stage I NSCLC and 11 with stage II NSCLC. Among 64 patients with stage I NSCLC, 35 patients showed recurrences whereas 8 patients have recurred in stage II NSCLC. Grade of differentiation of tumor was closely related to the recurrence. Seventy-five percent of patients who had poor tumor differentiation experienced a recurrence. In contrast, 3 patients of twelve had recurrences, who revealed differentiation in their tissue (p<0.05). CONCLUSION: Tumor differentiation could be a predictive factor for tumor recurrence in patients who have undergone curative resection for stage I or II NSCLC.
Sujet(s)
Mots clés
Texte intégral: 1 Indice: WPRIM Sujet Principal: Pronostic / Récidive / Marqueurs biologiques tumoraux / Différenciation cellulaire / Démographie / Facteurs de risque / Carcinome pulmonaire non à petites cellules / Corée / Poumon / Tumeurs du poumon Type d'étude: Etiology_studies / Prognostic_studies / Risk_factors_studies Limites du sujet: Female / Humans / Male Pays comme sujet: Asia langue: Ko Texte intégral: Tuberculosis and Respiratory Diseases Année: 2010 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Pronostic / Récidive / Marqueurs biologiques tumoraux / Différenciation cellulaire / Démographie / Facteurs de risque / Carcinome pulmonaire non à petites cellules / Corée / Poumon / Tumeurs du poumon Type d'étude: Etiology_studies / Prognostic_studies / Risk_factors_studies Limites du sujet: Female / Humans / Male Pays comme sujet: Asia langue: Ko Texte intégral: Tuberculosis and Respiratory Diseases Année: 2010 Type: Article