Cord Blood Soluble fms-Like Tyrosine Kinase 1 and Placental Growth Factor in Preterm Infants with Maternal Preeclampsia / 이화의대지
The Ewha Medical Journal
; : 118-125, 2013.
Article
de Ko
| WPRIM
| ID: wpr-71800
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVES: The purpose of this study was to investigate the relationship of cord blood levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and vascular endothelial growth factor (VEGF) in preterm infants with maternal preeclampsia. METHODS: Thirty six preterm infants born at Ewha Womans University Mokdong Hospital from January 2006 to August 2006 were studied after prior parental consent at mid-pregnancy. sFlt-1, PlGF, and VEGF levels in the cord blood of preterm neonate, with or without maternal preeclampsia, were measured using enzyme-linked immunosorbent assay. RESULTS: There was no difference in sFlt-1 between infants with and without maternal preeclampsia. Infants with maternal preeclampsia had significantly lower PlGF levels (P=0.035) and higher sFlt-1/PlGF ratio (P=0.080) with borderline significance. Cord blood VEGF levels were not related to maternal preeclampsia. Infants with maternal preeclampsia had lower birth weight (P=0.030), lower neonatal platelet count without statistical significance (P=0.064) and more likely to be small for gestational age (P=0.057). Neonatal platelet count was significantly correlated with cord blood PlGF levels (r=0.674, P=0.032). CONCLUSION: Increased sFlt-1/PlGF ratio and decreased PlGF may not only be related to the pathophysiology of maternal preeclampsia but also affect the neonatal platelet count and birth weight.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Numération des plaquettes
/
Pré-éclampsie
/
Poids de naissance
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Prématuré
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Récepteur-1 au facteur croissance endothéliale vasculaire
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Consentement parental
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Facteur de croissance endothéliale vasculaire de type A
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Sang foetal
Limites du sujet:
Female
/
Humans
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Infant
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Newborn
langue:
Ko
Texte intégral:
The Ewha Medical Journal
Année:
2013
Type:
Article