Effect of vitamin D deficiency in Korean patients with acute respiratory distress syndrome
The Korean Journal of Internal Medicine
; : 1129-1136, 2018.
Article
de En
| WPRIM
| ID: wpr-718019
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGROUND/AIMS: Vitamin D modulates innate and adaptive immune responses, and vitamin D deficiency is associated with increased mortality in hospitalized patients with pneumonia. We evaluated the prevalence of vitamin D deficiency in Korean patients with acute respiratory distress syndrome (ARDS) and its effect on the clinical outcomes of ARDS. METHODS: We retrospectively analyzed the data of 108 patients who had a measured serum level of 25-hydroxy vitamin D3 (25(OH)D3) at the time of diagnosis with ARDS. The clinical outcomes were evaluated based on 25(OH)D3 levels of 20 ng/mL and stratified by quartiles of 25(OH)D3 levels. RESULTS: The mean age of patients was 59.4 years old; 77 (71.3%) were male. Vitamin D deficiency was found in 103 patients (95.4%). The mean 25(OH)D3 level was 8.3 ± 7.0 ng/mL. Neither in-hospital mortality (40.0% vs. 68.0%) nor 6-month mortality (40.0% vs. 71.8%) significantly differed between groups. There were no significant differences in 25(OH)D3 level between survivors (8.1 ± 7.6 ng/mL) and non-survivors (8.5 ± 6.8 ng/mL, p = 0.765). There were no trends toward a difference in mortality among quartiles of 25(OH)D3 levels. However, 25(OH)D3 levels were inversely related with length of hospital stay and intensive care unit stay among in-hospital survivors. CONCLUSIONS: Vitamin D deficiency was prevalent in Korean patients with ARDS. However, levels of vitamin D were not associated with mortality. A large, prospective study is needed to evaluate the effects of vitamin D deficiency on clinical outcomes of ARDS.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pneumopathie infectieuse
/
Pronostic
/
12549
/
Vitamine D
/
Carence en vitamine D
/
Vitamines
/
Prévalence
/
Études prospectives
/
Études rétrospectives
/
Mortalité
Type d'étude:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
Limites du sujet:
Humans
/
Male
langue:
En
Texte intégral:
The Korean Journal of Internal Medicine
Année:
2018
Type:
Article