Atorvastatin pretreatment attenuates kainic acid-induced hippocampal neuronal death via regulation of lipocalin-2-associated neuroinflammation
The Korean Journal of Physiology and Pharmacology
; : 301-309, 2018.
Article
Dans En
| WPRIM
| ID: wpr-727588
Responsable en Bibliothèque :
WPRO
ABSTRACT
Statins mediate vascular protection and reduce the prevalence of cardiovascular diseases. Recent work indicates that statins have anticonvulsive effects in the brain; however, little is known about the precise mechanism for its protective effect in kainic acid (KA)-induced seizures. Here, we investigated the protective effects of atorvastatin pretreatment on KA-induced neuroinflammation and hippocampal cell death. Mice were treated via intragastric administration of atorvastatin for 7 days, injected with KA, and then sacrificed after 24 h. We observed that atorvastatin pretreatment reduced KA-induced seizure activity, hippocampal cell death, and neuroinflammation. Atorvastatin pretreatment also inhibited KA-induced lipocalin-2 expression in the hippocampus and attenuated KA-induced hippocampal cyclooxygenase-2 expression and glial activation. Moreover, AKT phosphorylation in KA-treated hippocampus was inhibited by atorvastatin pretreatment. These findings suggest that atorvastatin pretreatment may protect hippocampal neurons during seizures by controlling lipocalin-2-associated neuroinflammation.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Phosphorylation
/
Crises épileptiques
/
Encéphale
/
Maladies cardiovasculaires
/
Prévalence
/
Mort cellulaire
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Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase
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Cyclooxygenase 2
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Atorvastatine
/
Hippocampe
Type d'étude:
Prevalence_studies
Limites du sujet:
Animals
langue:
En
Texte intégral:
The Korean Journal of Physiology and Pharmacology
Année:
2018
Type:
Article