Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts from Artemisia annua L
The Korean Journal of Physiology and Pharmacology
; : 21-27, 2015.
Article
Dans En
| WPRIM
| ID: wpr-727830
Responsable en Bibliothèque :
WPRO
ABSTRACT
The anti-inflammatory, antioxidant, and antimicrobial properties of artemisinin derived from water, methanol, ethanol, or acetone extracts of Artemisia annua L. were evaluated. All 4 artemisinin-containing extracts had anti-inflammatory effects. Of these, the acetone extract had the greatest inhibitory effect on lipopolysaccharide-induced nitric oxide (NO), prostaglandin E2 (PGE2), and proinflammatory cytokine (IL-1beta , IL-6, and IL-10) production. Antioxidant activity evaluations revealed that the ethanol extract had the highest free radical scavenging activity, (91.0+/-3.2%), similar to alpha-tocopherol (99.9%). The extracts had antimicrobial activity against the periodontopathic microorganisms Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum subsp. animalis, Fusobacterium nucleatum subsp. polymorphum, and Prevotella intermedia. This study shows that Artemisia annua L. extracts contain anti-inflammatory, antioxidant, and antimicrobial substances and should be considered for use in pharmaceutical products for the treatment of dental diseases.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Acétone
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Préparations pharmaceutiques
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Eau
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Dinoprostone
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Maladies du système stomatognathique
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Interleukine-6
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Fusobacterium nucleatum
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Aggregatibacter actinomycetemcomitans
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Prevotella intermedia
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Alpha-Tocophérol
langue:
En
Texte intégral:
The Korean Journal of Physiology and Pharmacology
Année:
2015
Type:
Article