Correlation between body mass index and early graft function / 器官移植

ABSTRACT

Objective To investigate the correlation between body mass index (BMI)and early graft function.Methods Clinical data of 133 recipients underwent renal allograft transplantation in the Department of Nephropathy of the First Affiliated Hospital of Xinjiang Medical University from November 2003 to November 2014 were retrospectively studied.According to BMI before transplantation,the recipients were divided into 3 groupsemaciation group (BMI < 18.5 kg/m2 ),normal weight group (BMI of 18.5-23.9 kg/m2 )and overweight group (BMI >23.9 kg/m2 ).The laboratory indexes [blood urea nitrogen (BUN),serum creatinine (Scr),hemoglobin,serum albumin,total cholesterol and triglyceride]and the incidence of delayed graft function at 1 week after transplantation were compared among three groups.The correlation between Scr and BMI was analyzed.Results There was significant difference in Scr level among three groups (P <0.05).In pairwise comparison,Scr level of the overweight group was higher than that of the normal weight group and the difference had statistical significance (Z =-3.408,P =0.01 ).The hemoglobin,serum albumin and total cholesterol of the three groups showed no difference with statistical significance (all in P >0.05).The Scr level of renal transplant recipients was positively correlated with BMI (r =0.187,P =0.031),and Scr level raised with the increase of BMI.Conclusions BMI influences the recovery of early graft function.To control body weight before transplantation is beneficial to improve graft function.