Progress in research on cardiovascular magnetic resonance approach to assess myocarditis in children / 中华实用儿科临床杂志

ABSTRACT

Myocarditis is a common pediatric cardiovascular disease.Myocardial inflammation caused by myocardial cell edema,infiltration,apoptosis and necrosis,is one of the reasons leading to sudden cardiac death in children.Clinical symptoms of myocarditis has a wide variety,from asymptomatic to lethal performance,which caused difficulties to the clinical diagnostic for myocarditis.Endomyocardial biopsy is a widely accepted method for diagnosing myocarditis.The drawbacks of this method are reduced sensitivity given that myocarditis may be focal or regional,as well as lowered specificity due to interobserver variability.Cardiovascular magnetic resonance(CMR) can not only provide the cardiac anatomy and morphology information,but also can evaluate myocardial tissue characteristics including edema,hyperemia,fibrosis by measuring the T1 and T2 relaxation times and spin density.This article describes the pathology and research progress on CMR in detecting children myocarditis.