Effect of Resveratrol on Cell Differentiation and Mineralization in Cultured Odontoblasts
International Journal of Oral Biology
; : 133-140, 2018.
Article
de Ko
| WPRIM
| ID: wpr-740076
Bibliothèque responsable:
WPRO
ABSTRACT
Resveratrol (3,4′,5,-trihydroxystilbene), a phytoalexin present in grapes, exerts a variety of actions to reduce superoxides, prevents diabetes mellitus, and inhibits inflammation. Resveratrol acts as a chemo-preventive agent and induces apoptotic cell death in various cancer cells. However, the role of resveratrol in odontoblastic cell differentiation is unclear. In this study, the effect of resveratrol on regulating odontoblast differentiation was examined in MDPC-23 mouse odontoblastic cells derived from mouse dental papilla cells. Resveratrol significantly accelerated mineralization as compared with the control culture in differentiation of MDPC-23 cells. Resveratrol significantly increased expression of ALP mRNA as compared with the control in differentiation of MDPC-23 cells. Resveratrol significantly accelerated expression of ColImRNA as compared with the control in differentiation of MDPC-23 cells. Resveratrol significantly increased expressions of DSPP and DMP-1 mRNAs as compared with the control in differentiation of MDPC-23 cells. Treatment of resveratrol did not significantly affect cell proliferation in MDPC-23 cells. Results suggest resveratrol facilitates odontoblast differentiation and mineralization in differentiation of MDPC-23 cells, and may have potential properties for development and clinical application of dentin regeneration materials.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Régénération
/
ARN messager
/
Différenciation cellulaire
/
Mort cellulaire
/
Superoxydes
/
Vitis
/
Papille dentaire
/
Dentine
/
Prolifération cellulaire
/
Diabète
Limites du sujet:
Animals
langue:
Ko
Texte intégral:
International Journal of Oral Biology
Année:
2018
Type:
Article