Survival outcomes of adjuvant radiotherapy and chemotherapy in women with stage I serous papillary and clear cell carcinoma of the endometrium: a Korean multicenter study / 부인종양
Journal of Gynecologic Oncology
; : e44-2019.
Article
de En
| WPRIM
| ID: wpr-740195
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE: To compare the survival outcomes of adjuvant radiotherapy and chemotherapy in women with uterine-confined endometrial cancer with uterine papillary serous carcinoma (UPSC) or clear cell carcinoma (CCC). METHODS: Medical records of 80 women who underwent surgical staging for endometrial cancer were retrospectively reviewed. Stage I UPSC and CCC were pathologically confirmed after surgery. Survival outcomes were compared between the adjuvant radiotherapy and chemotherapy groups. RESULTS: Fifty-four (67.5%) and 26 (32.5%) women had UPSC and CCC, respectively. Adjuvant therapy was administered to 59/80 (73.8%) women (25 radiotherapy and 34 chemotherapy). High preoperative serum cancer antigen-125 level (25.1±20.2 vs. 11.5±6.5 IU/mL, p 0.999) and overall survival (77.5% vs. 87.8%, p=0.373) rates were similar between the groups. Neither radiotherapy (hazard ratio [HR]=1.810; 95% confidence interval [CI]=0.297–11.027; p=0.520) nor chemotherapy (HR=1.638; 95% CI=0.288–9.321; p=0.578) after surgery was independently associated with disease recurrence. CONCLUSION: Our findings showed similar survival outcomes for adjuvant radiotherapy and chemotherapy in stage I UPSC and CCC of the endometrium. Further large study with analysis stratified by MI or LVSI is required.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Radiothérapie
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Récidive
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Adénocarcinome papillaire
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Dossiers médicaux
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Études rétrospectives
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Tumeurs de l'endomètre
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Traitement médicamenteux adjuvant
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Adénocarcinome à cellules claires
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Radiothérapie adjuvante
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Survie sans rechute
Type d'étude:
Observational_studies
Limites du sujet:
Female
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Humans
langue:
En
Texte intégral:
Journal of Gynecologic Oncology
Année:
2019
Type:
Article