Prognostic factors for recurrence and survival in uterine leiomyosarcoma: Korean single center experience with 50 cases
Obstetrics & Gynecology Science
; : 103-111, 2019.
Article
Dans En
| WPRIM
| ID: wpr-741744
Responsable en Bibliothèque :
WPRO
ABSTRACT
OBJECTIVE:
The aim of this study was to determine the possible prognostic factors in patients with uterine leiomyosarcoma (LMS).METHODS:
This study retrospectively investigated 50 patients with uterine LMS treated at the Samsung Medical Center between 2001 and 2017. To analyze the prognostic significance of factors for recurrence-free survival (RFS), overall survival (OS), and survival after recurrence, the log-rank test and Cox proportional hazards model were used for univariate and multivariate analysis.RESULTS:
Of the 50 patients, 30 (60.0%) experienced recurrence and 16 (32.0%) died within a median follow-up period of 21 (range, 3–99) months. Multivariate analysis revealed that older age, absence of residual tumor after surgery, lower mitotic count, and a history of adjuvant radiotherapy at first treatment were significantly associated with better RFS. Presence of residual tumor after surgery and severe nuclear atypia were associated with poor OS. In the analysis of survival after recurrence, hematogenous recurrence, severe nuclear atypia, and presence of residual tumor at primary surgery were significantly associated with worse prognosis. Notably, residual tumor status at primary surgery was associated with RFS, OS, and survival after recurrence.CONCLUSION:
We demonstrated the possible prognostic factors for RFS, OS, and survival after recurrence for patients with LMS. These results may provide useful information for patients with LMS.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pronostic
/
Récidive
/
Tumeurs de l'utérus
/
Modèles des risques proportionnels
/
Analyse multifactorielle
/
Études rétrospectives
/
Études de suivi
/
Radiothérapie adjuvante
/
Maladie résiduelle
/
Léiomyosarcome
Type d'étude:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites du sujet:
Humans
langue:
En
Texte intégral:
Obstetrics & Gynecology Science
Année:
2019
Type:
Article