Impact on Survival of Regular Postoperative Surveillance for Patients with Early Breast Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 765-773, 2015.
Article
Dans En
| WPRIM
| ID: wpr-74287
Responsable en Bibliothèque :
WPRO
ABSTRACT
PURPOSE:
The purpose of this study is to evaluate the role of regular postoperative surveillance to improve the prognosis of patients with breast cancer after curative surgery. MATERIALS ANDMETHODS:
We retrospectively analyzed the medical records of 4,119 patients who received curative surgery for breast cancer at Samsung Medical Center between January 2000 and September 2008. Patients were divided into two groups (group I, regular postoperative surveillance; group II, control group) according to their post-therapy follow-up status for the first 5 years after surgery.RESULTS:
Among the 3,770 patients selected for inclusion, groups I and II contained 3,300 (87%) and 470 (13%) patients, respectively. The recurrence rates at 5 years for groups I and II were 10.6% and 16.4%, respectively (hazard ratio, 0.85; 95% confidence interval [CI], 0.67 to 1.09; p=0.197). The 10-year mortality cumulative rates were 8.8% for group I and 25.4% for group II (hazard ratio, 0.28; 95% CI, 0.22 to 0.35; p < 0.001). In multivariate analysis for recurrence-free survival (RFS), age over 40 years (p < 0.001), histologic grade 1 (p < 0.001), and pathologic stage I (p < 0.001) were associated with longer RFS but not with follow-up status. Multivariate analysis for overall survival (OS) revealed that patients in group I showed significantly improved OS (hazard ratio, 0.29; 95% CI, 0.23 to 0.37; p < 0.001). Additionally, age over 40 years, histologic grade I, and pathologic stage I were independent prognostic factors for OS.CONCLUSION:
Regular follow-up for patients with breast cancer after primary surgery resulted in clinically significant improvements in patient OS.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pronostic
/
Récidive
/
Région mammaire
/
Tumeurs du sein
/
Dossiers médicaux
/
Épidémiologie
/
Analyse multifactorielle
/
Études rétrospectives
/
Études de suivi
/
Mortalité
Type d'étude:
Observational_studies
/
Prognostic_studies
/
Screening_studies
Limites du sujet:
Humans
langue:
En
Texte intégral:
Cancer Research and Treatment
Année:
2015
Type:
Article