Estrogen receptor-β expression in laryngeal carcinoma: correlation with the expression of epithelial-mesenchymal transition specific biomarkers / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 921-924, 2015.
Article
de Zh
| WPRIM
| ID: wpr-747879
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE@#To detect the expression of ERβ in laryngeal carcinoma and the its correlation with the expression of epithelial-mesenchymal transition(EMT) specific biomarkers.@*METHOD@#Picture MT-Pv9000 was used to detect ERβ and EMT in 72 cases of human aqueous laryngeal carcinoma and 8 cases of adjacent non-neoplastic laryngeal mucosa by immunohistochemistry.@*RESULT@#The positive rates of ERβ in tumors and adjacent non-neoplastic laryngeal mucosa were 27.78% and 25.00%, respectively. The differences were not significant (P > 0.05). The abnormal expression rates of E-cadherin and β-catenin were 61.11% and 76.39% respectively. The expression of ERβ correlated negatively with the loss of E-cadherin, nuclear translocation of β-catenin and increased TNM stage. The differences were significant (P < 0.05).@*CONCLUSION@#The positive expressions of ERβ suggest a good prognosis in the differentiation, clinical stages and lymphatic metastasis of the laryngeal carcinoma. The underlying mechanism may be related with the abnormal expressions of E-cadherin and β-catenin.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Immunohistochimie
/
Marqueurs biologiques tumoraux
/
Antigènes CD
/
Cadhérines
/
Tumeurs du larynx
/
Récepteur bêta des oestrogènes
/
Bêta-Caténine
/
Transition épithélio-mésenchymateuse
/
Métastase lymphatique
/
Métabolisme
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Année:
2015
Type:
Article