The expression of serum IL-10,12,13,16 in patients with allergic rhinitis and vasomotor rhinitis / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 913-915, 2007.
Article
de Zh
| WPRIM
| ID: wpr-748314
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE@#To study the role of serum IL-10, 12, 13, 16 in patients with allergic rhinitis and vasomotor rhinitis.@*METHOD@#The serum levels of IL-10, 12, 13, 16 were measured by ELISA in 30 cases of allergic rhinitis, 25 cases of vasomotor rhinitis and 20 healthy people.@*RESULT@#The level of IL-12 in allergic rhinitis was (170.33 +/- 90.58) ng/L, which was significantly lower than that of normal controls [(376.69 +/- 140.70) ng/L, P < 0.01]. The levels of IL-13 and IL-16 in allergic rhinitis were (408.51 +/- 189.68) ng/L and (151.53 +/- 63.56) ng/L, which were significantly higher than those of normal controls [(151.92 +/- 85.08) ng/L, (60.65 +/- 32.45) ng/L, P < 0.01]. There were no significant difference of levels of IL-10, 13, 16 between vasomotor rhinitis and normal controls, while the level of IL-12 in vasomotor rhinitis was lower than that of normal controls [(196.03 +/- 96.31) ng/L vs. (376.69 +/- 140.70) ng/L, P < 0.01]. It was suggested that IL-10 had positive correlation with IL-12 (r = 0.73, P < 0.01), and IL-13 had positive correlation with IL-16 (r = 0.94, P < 0.01).@*CONCLUSION@#The imbalance of IL-12, IL-13 and IL-16 play crucial roles of regulation in the onset and developing of allergic rhinitis. Further research is needed on the role of IL-12 in vasomotor rhinitis.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Sang
/
Études cas-témoins
/
Rhinite spasmodique apériodique
/
Rhinite vasomotrice
/
Rhinite allergique saisonnière
/
Interleukine-10
/
Interleukine-13
/
Interleukine-12
/
Interleukine-16
Type d'étude:
Observational_studies
Limites du sujet:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
langue:
Zh
Texte intégral:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Année:
2007
Type:
Article