Gynecomastia induced by H1-antihistamine (ebastine) in a patient with idiopathic anaphylaxis
Asia Pacific Allergy
; (4): 187-190, 2015.
Article
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| ID: wpr-750027
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ABSTRACT
H1-antihistamine is generally a well-tolerated and safe drug. However, in resemblance with all other drugs, H1-antihistamines can also prompt adverse drug reactions (ADRs). We recently encountered the very unusual ADR of H1-antihistamine-induced gynecomastia. A 21-year-old man with idiopathic anaphylaxis was treated with ebastine (Ebastel), a second-generation H1-antihistamine, for the prevention of anaphylaxis. Three months later, the patient remained well without anaphylaxis, but had newly developed gynecomastia. Because anaphylaxis recurred after the cessation of H1-antihistamine, the preventive medication was changed to omalizumab. A few months later, his gynecomastia had entirely disappeared. Physicians should be aware of this exceptional ADR of H1-antihistamine.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Effets secondaires indésirables des médicaments
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Omalizumab
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Gynécomastie
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Antihistaminiques des récepteurs H1
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Anaphylaxie
Limites du sujet:
Humans
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Male
langue:
En
Texte intégral:
Asia Pacific Allergy
Année:
2015
Type:
Article