Relationship between microRNAs and myopia / 中华实验眼科杂志

ABSTRACT

MicroRNA (miRNA) is a kind of non-coding small RNAs,which can regulate target mRNA at post-transcriptional level and play an important regulatory role in a variety of biological processes in epigenetics field.Myopia is a complex disease caused by both genetic and environmental factors.Recently,epigenetic regulation has been found to be closely related to pathogenesis of myopia,in which miRNA play an important role.This article briefly introduced structure and function of miRNAs,differential expression of miRNA in ocular tissues (retina and sclera) and miRNA regulation of myopia-related genes,such as paired box 6 (PAX6),type Ⅰ collagen α1 chain (COL1A1) and matrix metalloproteinase 2 (MMP2).The progress of miRNAs research was reviewed.