The relationship between thyroid stimulating hormone within normal range and several metabolic indexes in type 2 diabetes mellitus / 中国医师进修杂志

ABSTRACT

Objective To investigate the relationship between thyroid stimulating hormone(TSH) and uric acid (UA), blood pressure, blood glucose, blood lipid and body mass index (BMI) in patients with type 2 diabetes. Methods A total of 254 patients with type 2 diabetes and normal thyroid function who were admitted to the Shengjing Hospital Affiliated to China Medical University from 2017 to 2019 were selected. Height, weight, systolic blood pressure (SBP) and diastolic blood pressure (DBP) and test fasting blood glucose (FBG), glycated hemoglobin (HbA1c), total cholesterol (TC), triacylglycerol (TG), low density lipoprotein cholestorol (LDL-C), free triiodothyronine (FT3), free theroxine (FT4), TSH and UA was measured. The correlations between TSH and blood pressure, blood lipid, FBG, BMI and UA was analyzed. Results According to gender, there were two groups. The levels of FT3, UA and BMI of males were significantly higher than that of females (P<0.05). Age, course of disease, TSH and TC of females were significantly higher than that of males (P<0.05). According to the TSH values of males and females, 254 patients were divided into TSH < 2.5 mU/L group and TSH ≥ 2.5 mU/L group respectively. The levels of BMI, FBG and UA in TSH≥2.5 mU/L group were significantly higher than those in TSH<2.5 mU/L group within females:(26.38 ± 4.06)kg/m2 vs.(23.91 ± 2.79)kg/m2,(10.29 ± 4.52)mmol/L vs. (8.38 ± 2.72)mmol/L,(406.53 ± 79.48)μmol/L vs.(270.17 ± 17.15)μmol/L. The levels of BMI, DBP and UA in TSH≥2.5 mU/L group were significantly higher than those in TSH<2.5 mU/L group within males:(27.87 ± 3.85)kg/m2 vs.(25.09 ± 3.10)kg/m2,(85.98 ± 9.75)mmHg(1 mmHg＝0.133 kPa) vs. (80.79 ± 8.44)mmHg,(430.35 ± 101.01)μmol/L vs.(318.10 ± 65.25)μmol/L, and the differences were statistically significant (P<0.05). Pearson correlation analysis was used to analyze the correlation between TSH and various indexes of all selected subjects. Only BMI, UA, FT4 and TG were statistically significant, and the correlation coefficients were 0.297, 0.550, - 0.208 and 0.127, P < 0.05, respectively. BMI, FBG and UA levels of females were positively correlated with TSH (P < 0.05), and the correlation coefficients were 0.332, 0.219 and 0.632, respectively. BMI, DBP, HbA1c and UA of males were positively correlated with TSH (P<0.05), and the correlation coefficients were 0.316, 0.204, 0.176 and 0.541, respectively. FT4 was negatively correlated with TSH, with a correlation coefficient of 0.248, which was statistically significant (P < 0.05), and UA had a stronger correlation with TSH. Conclusions Even in type 2 diabetics with normal thyroid function, small changes in TSH can affect weight, UA, FBG in women and DBP in men.