Evolutionary relationship analysis of Middle East respiratory syndrome coronavirus 4a and 4b protein coding sequences
Journal of Veterinary Science
; : e1-2019.
Article
Dans En
| WPRIM
| ID: wpr-758906
Responsable en Bibliothèque :
WPRO
ABSTRACT
The 4a and 4b proteins of the Middle East respiratory syndrome coronavirus (MERS-CoV) have been described for their antagonism on host innate immunity. However, unlike clustering patterns of the complete gene sequences of human and camel MERS-CoVs, the 4a and 4b protein coding regions did not constitute species-specific phylogenetic groups. Moreover, given the estimated evolutionary rates of the complete, 4a, and 4b gene sequences, the 4a and 4b proteins might be less affected by species-specific innate immune pressures. These results suggest that the 4a and 4b proteins of MERS-CoV may function against host innate immunity in a manner independent of host species and/or evolutionary clustering patterns.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Phylogenèse
/
Chameaux
/
Zoonoses
/
Cadres ouverts de lecture
/
Infections à coronavirus
/
Évolution moléculaire
/
Codage clinique
/
Coronavirus du syndrome respiratoire du Moyen-Orient
/
Immunité innée
/
Moyen Orient
Limites du sujet:
Humans
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Journal of Veterinary Science
Année:
2019
Type:
Article