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Dioscorea japonica Thunb. Ethanolic Extract Attenuated Oxazolone-Induced Atopic Dermatitis-like Skin Lesions in BALB/c Mice
Natural Product Sciences ; : 261-267, 2019.
Article de En | WPRIM | ID: wpr-760562
Bibliothèque responsable: WPRO
ABSTRACT
The rhizomes of Dioscorea japonica Thunb. are widely consumed as food and also used to treat diabetes and polyuria in Korea. This study was undertaken to study the anti-atopic dermatitis effects of a 95% ethanolic extract (DJE) of D. japonica in an oxazolone-stimulated murine model of atopic dermatitis (AD). The therapeutic effects of DJE on AD-like skin lesions were assessed on both ears. DJE (1%) or dexamethasone (0.5%; the positive control) were applied to skin lesions for three weeks. Serum levels of IgE and IL-4 were assessed by ELISA (enzyme-linked immunosorbent assay). Histopathological examinations were performed by hematoxylin and eosin (H&E) and toluidine blue staining and revealed DJE significantly reduced dermal thickness and inflammatory cell infiltration when applied to oxazolone-treated ear skin. DJE-treated AD mice also showed lower serum levels of IgE and IL-4 than oxazolone-stimulated controls. Our findings demonstrate DJE might be a useful safe, topical agent for the treatment of atopic diseases.
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Texte intégral: 1 Indice: WPRIM Sujet Principal: Polyurie / Peau / Chlorure de tolonium / Immunoglobuline E / Dexaméthasone / Test ELISA / 4-Éthoxyméthylène-2-phényl-oxazol-5(4H)-one / Interleukine-4 / Éosine jaunâtre / Dioscorea Type d'étude: Prognostic_studies Limites du sujet: Animals Pays comme sujet: Asia langue: En Texte intégral: Natural Product Sciences Année: 2019 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Polyurie / Peau / Chlorure de tolonium / Immunoglobuline E / Dexaméthasone / Test ELISA / 4-Éthoxyméthylène-2-phényl-oxazol-5(4H)-one / Interleukine-4 / Éosine jaunâtre / Dioscorea Type d'étude: Prognostic_studies Limites du sujet: Animals Pays comme sujet: Asia langue: En Texte intégral: Natural Product Sciences Année: 2019 Type: Article