Sirolimus therapy for fetal cardiac rhabdomyoma in a pregnant woman with tuberous sclerosis
Obstetrics & Gynecology Science
; : 280-284, 2019.
Article
Dans En
| WPRIM
| ID: wpr-760646
Responsable en Bibliothèque :
WPRO
ABSTRACT
Rhabdomyoma is the most common fetal cardiac tumor, and its development is related to tuberous sclerosis. Fetal cardiac rhabdomyomas often spontaneously regress in utero or after birth, but large tumors can cause hemodynamic obstruction. Sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, has been used as an immunosuppressant after organ transplantation. The mTOR inhibitors are well-known to have anti-tumor activity, and they have been used for the treatment of patients with tuberous sclerosis. In the current case, fetal cardiac rhabdomyoma was completely resolved in utero during oral sirolimus treatment in the mother with tuberous sclerosis. This case shows that oral sirolimus therapy in pregnancy may be a treatment for multiple or large fetal cardiac rhabdomyomas.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Rhabdomyome
/
Complexe de la sclérose tubéreuse
/
Transplantation d'organe
/
Transplants
/
Sirolimus
/
Parturition
/
Femmes enceintes
/
Thérapies foetales
/
Tumeurs du coeur
/
Hémodynamique
Limites du sujet:
Female
/
Humans
/
Pregnancy
langue:
En
Texte intégral:
Obstetrics & Gynecology Science
Année:
2019
Type:
Article