Immunoregulatory effects of Tripterygium wilfordii Hook F and its extracts in clinical practice / 医学前沿
Frontiers of Medicine
; (4): 556-563, 2019.
Article
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| WPRIM
| ID: wpr-771269
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WPRO
ABSTRACT
Tripterygium wilfordii Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewed their effects for use in clinical practice. This review provides a comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinical studies. TwHF and its extracts affect the proliferation and activation of Tand B cells; ratio of Tcell subsets; inflammatory response of monocytes, macrophages, and immunoglobulins; and secretion of many cytokines. Together, these effects dictate immune function in a variety of diseases. TwHF and its extracts can be used alone or in combination with existing therapies against many immune disorders through immunomodulation.
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WPRIM
langue:
En
Texte intégral:
Frontiers of Medicine
Année:
2019
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Article