Monitoring Value of Multimodal Magnetic Resonance Imaging in Disease Progression of Amyotrophic Lateral Sclerosis: A Prospective Observational Study / 中华医学杂志(英文版)
Chin. med. j
; Chin. med. j;(24): 2904-2909, 2018.
Article
de En
| WPRIM
| ID: wpr-772895
Bibliothèque responsable:
WPRO
ABSTRACT
Background@#Ongoing efforts have been made to identify new neuroimaging markers to track amyotrophic lateral sclerosis (ALS) progression. This study aimed to explore the monitoring value of multimodal magnetic resonance imaging (MRI) in the disease progression of ALS.@*Methods@#From September 2015 to March 2017, ten patients diagnosed with ALS in Peking Union Medical College Hospital completed head MRI scans at baseline and during follow-up. Multimodal MRI analyses, including gray matter (GM) volume measured by voxel-based morphometry; cerebral blood flow (CBF) evaluated by arterial spin labeling; functional connectivity, including low-frequency fluctuation (fALFF) and regional homogeneity (ReHo), measured by resting-state functional MRI; and integrity of white-matter (WM) fiber tracts evaluated by diffusion tensor imaging, were performed in these patients. Comparisons of imaging metrics were made between baseline and follow-up using paired t-test.@*Results@#In the longitudinal comparisons, the brain structure (GM volume of the right precentral gyri, left postcentral gyri, and right thalami) and perfusion (CBF of the bilateral temporal poles, left precentral gyri, postcentral gyri, and right middle temporal gyri) in both motor and extramotor areas at follow-up were impaired to different extents when compared with those at baseline (all P < 0.05, false discovery rate adjusted). Functional connectivity was increased in the motor areas (fALFF of the right precentral gyri and superior frontal gyri, and ReHo of right precentral gyri) and decreased in the extramotor areas (fALFF of the bilateral middle frontal gyri and ReHo of the right precuneus and cingulate gyri) (all P < 0.001, unadjusted). No significant changes were detected in terms of brain WM measures.@*Conclusion@#Multimodal MRI could be used to monitor short-term brain changes in ALS patients.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Encéphale
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Imagerie diagnostique
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Imagerie par résonance magnétique
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Circulation cérébrovasculaire
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Études prospectives
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Évolution de la maladie
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Imagerie multimodale
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Sclérose latérale amyotrophique
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Méthodes
Type d'étude:
Diagnostic_studies
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Observational_studies
Limites du sujet:
Adult
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Female
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Humans
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Male
langue:
En
Texte intégral:
Chin. med. j
Année:
2018
Type:
Article