A new isobenzofuranone derivative from Chaenomeles sinensis and its antibacterial activity / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3745-3748, 2019.
Article
de Zh
| WPRIM
| ID: wpr-773657
Bibliothèque responsable:
WPRO
ABSTRACT
A new isobenzofuranone derivative was isolated from Chaenomeles sinensis by using various chromatographic techniques,including silica gel,Sephadex LH-20,MCI-gel resin and RP-HPLC. This compound was determined as 2,2-dimethyl-5-( 2-oxopropyl)-2 H-furo[3,4-h]chromen-7( 9 H)-one( 1) by NMR,MS,IR and UV spectra,and was also evaluated for its antibacterial activity. The results showed that it showed prominent antibacterial activity with MIC90 value of( 53. 7±4. 5) mg·L-1 for methicillin resistant Staphylococcus aureus( MRSA) strain. This value is close to that of levofloxacin [with MIC90 value( 50. 2± 4. 2) mg·L-1].
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
/
Benzofuranes
/
Tests de sensibilité microbienne
/
Chimie
/
Chromatographie en phase liquide à haute performance
/
Rosaceae
/
Staphylococcus aureus résistant à la méticilline
/
Composés phytochimiques
/
Antibactériens
langue:
Zh
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2019
Type:
Article