A new isobenzofuranone derivative from Phlomis betonicoides and its antibacterial activity / 中国中药杂志
Zhongguo Zhong Yao Za Zhi
; (24): 4074-4076, 2018.
Article
de Zh
| WPRIM
| ID: wpr-775376
Bibliothèque responsable:
WPRO
ABSTRACT
A new isobenzofuranone derivative has been isolated from Phlomis betonicoides by using various chromatographic techniques, including silica gel, Sephadex LH-20, MCI-gel resin and RP-HPLC. This compound was determined as 5-(3-hydroxypropyl)-2,2-dimethyl-2-furo[3,4-]chromen-7(9)-one (1) by NMR, MS, IR and UV spectroscopic data. Compound 1 showed potent antibacterial activity with an MIC₉₀ value of (58.4 ± 4.2) mg·L⁻¹ for methicillin resistant Staphylococcus aureus (MRSA) strain [levofloxacin as a control with MIC₉₀ value of (52.8±4.6) mg·L⁻¹].
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
/
Benzofuranes
/
Tests de sensibilité microbienne
/
Chimie
/
Phlomis
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Staphylococcus aureus résistant à la méticilline
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Composés phytochimiques
/
Antibactériens
langue:
Zh
Texte intégral:
Zhongguo Zhong Yao Za Zhi
Année:
2018
Type:
Article