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Clinical Research on Alzheimer's Disease: Progress and Perspectives / 神经科学通报·英文版
Neuroscience Bulletin ; (6): 1111-1118, 2018.
Article Dans En | WPRIM | ID: wpr-775511
Responsable en Bibliothèque : WPRO
ABSTRACT
Alzheimer's disease (AD), the most common type of dementia, is becoming a major challenge for global health and social care. However, the current understanding of AD pathogenesis is limited, and no early diagnosis and disease-modifying therapy are currently available. During the past year, significant progress has been made in clinical research on the diagnosis, prevention, and treatment of AD. In this review, we summarize the latest achievements, including diagnostic biomarkers, polygenic hazard score, amyloid and tau PET imaging, clinical trials targeting amyloid-beta (Aβ), tau, and neurotransmitters, early intervention, and primary prevention and systemic intervention approaches, and provide novel perspectives for further efforts to understand and cure the disease.
Sujets)

Texte intégral: 1 Indice: WPRIM Sujet Principal: Thérapeutique / Sang / Imagerie par résonance magnétique / Marqueurs biologiques / Évolution de la maladie / Recherche biomédicale / Diagnostic / Maladie d'Alzheimer / Méthodes Type d'étude: Diagnostic_studies / Screening_studies Limites du sujet: Animals / Humans langue: En Texte intégral: Neuroscience Bulletin Année: 2018 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Thérapeutique / Sang / Imagerie par résonance magnétique / Marqueurs biologiques / Évolution de la maladie / Recherche biomédicale / Diagnostic / Maladie d'Alzheimer / Méthodes Type d'étude: Diagnostic_studies / Screening_studies Limites du sujet: Animals / Humans langue: En Texte intégral: Neuroscience Bulletin Année: 2018 Type: Article