Advances in the treatment of juvenile myelomonocytic leukemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 958-963, 2018.
Article
Dans Zh
| WPRIM
| ID: wpr-776685
Responsable en Bibliothèque :
WPRO
ABSTRACT
Juvenile myelomonocytic leukemia (JMML) is a rare chronic myeloid leukemia in children and has the features of both myelodysplastic syndrome and myeloproliferative neoplasm. It is highly malignant and has a poor treatment outcome. Children with JMML have a poor response to conventional chemotherapy. At present, hematopoietic stem cell transplantation is the only possible cure for this disease. In recent years, significant progress has been made in targeted therapy for mutant genes in the Ras signaling pathway and demethylation treatment of aberrant methylation of polygenic CpG islands. This article reviews the treatment and efficacy evaluation of JMML.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Syndromes myélodysplasiques
/
Transduction du signal
/
Transplantation de cellules souches hématopoïétiques
/
Leucémie myélomonocytaire juvénile
/
Méthylation
Limites du sujet:
Child
/
Humans
langue:
Zh
Texte intégral:
Chinese Journal of Contemporary Pediatrics
Année:
2018
Type:
Article